The DRD2 TaqIA polymorphism and demand of dopaminergic medication in Parkinson's disease
Identifieur interne : 002604 ( Main/Exploration ); précédent : 002603; suivant : 002605The DRD2 TaqIA polymorphism and demand of dopaminergic medication in Parkinson's disease
Auteurs : Sebastian Paus [Allemagne] ; Anne Grünewald [Allemagne] ; Christine Klein [Allemagne] ; Michael Knapp [Allemagne] ; Alexander Zimprich [Allemagne] ; Bernd Janetzky [Allemagne] ; Jens C. Möller [Allemagne] ; Thomas Klockgether [Allemagne] ; Ullrich Wüllner [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-03-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Chemotherapy, DRD2, Dopamine Agonists (therapeutic use), Female, Genotype, German, German Competence Network on PD, Humans, Levodopa, Levodopa (therapeutic use), Male, Middle Aged, Nervous system diseases, Parkinson Disease (drug therapy), Parkinson Disease (genetics), Parkinson disease, Parkinson's disease, Polymorphism, Polymorphism, Genetic (genetics), Receptors, Dopamine D2 (genetics), Treatment Outcome, levodopa, pharmacogenetics.
- MESH :
- chemical , genetics : Receptors, Dopamine D2.
- chemical , therapeutic use : Dopamine Agonists, Levodopa.
- drug therapy : Parkinson Disease.
- genetics : Parkinson Disease, Polymorphism, Genetic.
- Aged, Female, Genotype, Humans, Male, Middle Aged, Treatment Outcome.
Abstract
Previous studies have demonstrated that the TaqIA polymorphism of the D2 dopamine receptor gene (DRD2) is associated with response to dopaminergic and antidopaminergic treatment in Parkinson's disease (PD) and schizophrenia, respectively. We tested whether the TaqIA genotype in PD is responsible for demand of dopaminergic medication, measured in total dopaminergic load per year of disease, in a large scale association study based on the gene bank of the German Competence Network on Parkinson's disease. Regression analysis yielded no significant differences between the TaqIA genotypes. We conclude that the DRD2 TaqIA polymorphism alone has no pivotal role for interindividual variability of dopaminergic requirement in PD. We propose a practicable system of measuring dopaminergic treatment for future pharmacogenetic studies in PD. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21901
Affiliations:
- Allemagne
- Bade-Wurtemberg, District de Cologne, District de Dresde, District de Giessen, District de Tübingen, Hesse (Land), Rhénanie-du-Nord-Westphalie, Saxe (Land)
- Bonn, Dresde, Marbourg, Tübingen
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Le document en format XML
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We tested whether the TaqIA genotype in PD is responsible for demand of dopaminergic medication, measured in total dopaminergic load per year of disease, in a large scale association study based on the gene bank of the German Competence Network on Parkinson's disease. Regression analysis yielded no significant differences between the TaqIA genotypes. We conclude that the DRD2 TaqIA polymorphism alone has no pivotal role for interindividual variability of dopaminergic requirement in PD. We propose a practicable system of measuring dopaminergic treatment for future pharmacogenetic studies in PD. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Cologne</li><li>District de Dresde</li><li>District de Giessen</li><li>District de Tübingen</li><li>Hesse (Land)</li><li>Rhénanie-du-Nord-Westphalie</li><li>Saxe (Land)</li></region><settlement><li>Bonn</li><li>Dresde</li><li>Marbourg</li><li>Tübingen</li></settlement></list><tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Paus, Sebastian" sort="Paus, Sebastian" uniqKey="Paus S" first="Sebastian" last="Paus">Sebastian Paus</name></region><name sortKey="Grunewald, Anne" sort="Grunewald, Anne" uniqKey="Grunewald A" first="Anne" last="Grünewald">Anne Grünewald</name><name sortKey="Janetzky, Bernd" sort="Janetzky, Bernd" uniqKey="Janetzky B" first="Bernd" last="Janetzky">Bernd Janetzky</name><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name><name sortKey="Knapp, Michael" sort="Knapp, Michael" uniqKey="Knapp M" first="Michael" last="Knapp">Michael Knapp</name><name sortKey="Moller, Jens C" sort="Moller, Jens C" uniqKey="Moller J" first="Jens C." last="Möller">Jens C. Möller</name><name sortKey="Wullner, Ullrich" sort="Wullner, Ullrich" uniqKey="Wullner U" first="Ullrich" last="Wüllner">Ullrich Wüllner</name><name sortKey="Zimprich, Alexander" sort="Zimprich, Alexander" uniqKey="Zimprich A" first="Alexander" last="Zimprich">Alexander Zimprich</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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